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Environmentally Sensible Organocatalytic Fmoc/t Bu Solid-Phase Peptide Synthesis
28 Feb 2022 - We now report a proof-of-principle Fmoc/t-Bu SPPS in which both couplings and Fmoc deprotections were catalyzed by readily available reagents in an inexpensive green solvent. […]
Read moreSPPS: Process improvements to reduce solvent consumption
31 Jan 2022 - Introducing a new percolation wash concept for solid-phase peptide synthesis .[…]
Read moreCircular Aqueous Fmoc/t-Bu Solid-Phase Peptide Synthesis
16 Jul 2021 - Circular economy and aqueous synthesis are attractive concepts for sustainable chemistry. Here it is reported that the two can be combined in the universal method for peptide chemistry, fluorenylmethoxycarbonyl(Fmoc)/t-Bu solid-phase peptide synthesis (SPPS). […]
Read moreDownstream Processes for peptide manufacturing: Optimization strategy and latest technical trends
2 Apr 2021 - This article highlights the key steps in the development and implementation of a proper purification strategy for the manufacture of peptide APIs. Our ambition is to recommend a structured methodology, including a good understanding of the separation mechanism to develop the process and to apply the latest technologies for the optimization of the purification step to reach the best performance of the manufacturing process. […]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
11 Mar 2021 - Dalton, C.; Diorazio, L. J.; Doerfler, J.; Engl, O. D.; Han, Z. S.; Howell, G. P.; Latham, J.; Li, W.; McLaws, M.; Munday, R. H.; Navarro, […]
Read moreMinimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions
16 Mar 2020 - Webinar Abstract: Diisopropylcarbodiimide (DIC) and ethyl (hydroxyimino)cyanoacetate (Oxyma) are the most widely used coupling reagents in peptide synthesis. McFarland et al. recently discovered the reaction between DIC and Oxyma, which forms hydrogen cyanide (HCN), […]
Read moreSelection of publications on significant advances in production and use of Peptides
1 Mar 2020 - We would like to share a selection of 10 publications reporting significant advances concerning production and use of Peptides, by Jan Pawlas, Ph.D. Scientist, Global Development, […]
Read moreSustainable, cost-efficient manufacturing of therapeutic peptides using chemo-enzymatic peptide synthesis (CEPS)
22 Nov 2019 - Using a large scale biocatalytic manufacture of the antidiabetic exenatide as an example, we report that chemo-enzymatic peptide synthesis (CEPS) constitutes an efficient method for sustainable manufacturing of therapeutic peptides. […]
Read moreQA interview: Focus innovation
21 Oct 2019 - Interview with Olivier Ludemann-Hombourger, Ph.D. Global Director Innovation & Technology of PolyPeptide Group […]
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